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CAFE4DM

Technical machinery

Process Analytics

The overall aims of WP3 are to develop a suite of in-line techniques to enable the rapid development and manufacture of new formulated products.

We will focus on the current inadequacies of characterising liquid properties in standard benchtop equipment through replacing these measurements with accurate, real-time, in-line measurements at pilot and manufacturing scale.

WP3.1 Experimental test rigs (batch and continuous flow) (Fonte, Rodgers, Martin(Peter), Martin, Kowalski, Baker)

  • Modification of existing rigs for in-line instrumentation Implement distributed control system

WP3.2 In-situ spectroscopy (Martin, Mendoza, Mihailova)

  • In situ Near-IR, FTIR, Raman

WP3.3 In-process fibre optic sensor applications (Scully, Martin, Mendoza, Kowlaski)

  • Measurements of stress, birefringence, fluorescence

WP3.4 Shear-banding and wall characterisation (Waigh, Mendoza)

  • Optical coherence tomography

WP3.5 Proxy measurement of viscosity (Rodgers, Baker)

  • eg, electrical impedance tomography

WP3.6 Process data analytics and control (Lennox, Hayes)

  • Application and development of linear and non-linear multivariate statistical methodologies to extract actionable information from the data that can be used in control systems.
In situ process analytical technology on mixing vessels

In situ process analytical technology on mixing vessels.

Part of a control panel for process data acquisition

Part of a control panel for process data acquisition.

Electrical Resistance Tomography producing online measurements of the local gas concentration in a multi-phase stirred tank

Electrical Resistance Tomography producing online measurements of the local gas concentration in a multi-phase stirred tank.

Electrical Resistance Tomography sensors on an inline production with a Silverson high shear mixer

Electrical Resistance Tomography sensors on an inline production with a Silverson high shear mixer.

Monitoring the tangential swirl in an agitated vessel with Electrical Resistance Tomography during crystallisation.

Monitoring the tangential swirl in an agitated vessel with Electrical Resistance Tomography during crystallisation. The red area represents a high concentration of crystals and the blue area represents a low concentration.